Detail introduction: Selank Acetate/129954-34-3
| English name | Selank |
| CAS NO | 129954-34-3 |
| Peptide sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular formula | C33H57N11O9 |
| Molecular weight | 751.87 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Selank Acetate; PL14736 |
What Is Selank?
Selank, also known as TP-7, is a synthetic peptide derived by combining the sequence of tuftsin with another sequence to improve its stability. Tuftsin makes up one part of the IgG antibody and is naturally occurring.
Tuftsin Definition: A peptide closely related to the immune function primarily supported by the spleen.
What Are the Potential Benefits of PL14736?
1. May Improve Anxiety
It can help in taming down anxious feelings.
It is an anxiolytic peptide, which helps combat stress and anxiety.
2. May Improve Learning Ability
3. May Enhance Memory
How Does PL14736 Work?
1. Reducing the breakdown of enkephalins
It works by inhibiting the enzymes responsible for breaking down enkephalin.
This finding has been confirmed in both human serum and anxiety-ridden patients.
2. Demonstrates anti-inflammatory properties
Selank acetate didn’t lose any of the immunity properties possessed by the naturally-occurring peptide tuftsin, as it can help induce your body into an anti-inflammatory state.
Tuftsin shifts the immune response from an inflammatory response to an anti-inflammatory response. It does this by shifting T helper cells from Th1/TH17 turn into Th2/Treg (ie TNF-a -> IL-4, IL-10, TGFb1). Tuftsin (like ghrelin) can shift microglia into a M2 microglial anti-inflammatory response.
It can decrease the expression of IL-6 and balance T helper cells’ production of cytokines PL14736effects the XCL1–XCR1 axis, Il2rg gene expression and C3 gene expression.”
A significant increase (p<0,05) of IL-6 concentration was observed in the cell culture of peripheral blood of patients in the presence of PL14736. The changes of the Th1/Th2 cytokine balance in vivo were found in the serum of patients with generalized anxiety disorder and neurasthenia who received Selank for 14 days.
3. Increased BDNF production
BDNF regulates short-term synaptic functions, as well as long-term synaptic potentiation via binding with specific TrkB receptors on postsynaptic neurons. The increase in BDNF mRNA expression in the hippocampus after learning has also been shown. A decrease in endogenous BDNF levels in the rat brain using BDNF antibodies or antisense oligonucleotides impairs learning and memory.
How to buy Selank in the U. S.
Peptide supplier Remetide specializes in the production and sales of peptides in the USA, as well as Professional Drug peptide R&D. Feel free to contact us if you have any questions or inquiries about Peptides.