Detail introduction: Alarelin/Alarelin acetate/79561-22-1
| English name | Alarelin |
| CAS NO | 79561-22-1 |
| Peptide sequence | Glp-His-Trp-Ser-Tyr-DAla-Leu-Arg-Pro-NHEt |
| Molecular formula | C56H78N16O12 |
| Molecular weight | 1167.32 |
| storage temperature | 2-8℃ |
| purity | ≥98% |
| Package | 1mg;5mg;10mg;50mg;100mg,1g or according to customer’s detail requirement. |
| Product English synonyms | Alarelin acetate |
What is Alarelin?
Alarelin is a nonapeptide analogue of synthetic gonadotropin-releasing hormone (GnRH), and its efficacy is 15 times that of the parent. In the early stage of medication, it can stimulate the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a temporary increase in ovarian-derived steroid hormones; repeated medication can inhibit the release of LH and FSH from the pituitary, and reduce the level of estradiol in the blood. To achieve the effect of the drug ovariectomy, at the same time it has a regulatory effect on the expression of the related oncogenes ras, neu, and myc of endometrial cancer. Clinically, it is mainly used to promote ovulation, treat infertility caused by abnormal ovarian function, endometriosis and uterine fibroids, and improve the pregnancy rate.
The use of Alarelin in medicine
This product is a nonapeptide analogue of synthetic gonadotropin-releasing hormone (GnRH), which can stimulate the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at the initial stage of treatment, causing a temporary increase in ovarian-derived steroid hormones; Repeated medication can inhibit the release of LH and FSH from the pituitary gland, reduce the level of estradiol in the blood, and achieve the effect of drug ovariectomy. This inhibitory effect can be used to treat hormone-dependent diseases such as endometriosis.
Alarelin’s mechanism of action
By detecting the expression of key intermediary proteins Smad2/3 and Smad7 in the TGF-β/smads signal transduction pathway in endometrial cancer transplanted tumor tissues, it indicates that the TGF-β1/smads signal transduction pathway may be the pathogenesis of endometrial cancer An important pathway in the mechanism. Alarelin may inhibit the occurrence and development of endometrial cancer by up-regulating Smad2/3 and down-regulating the expression of Smad7 protein.
Main purpose
Clinically, it is mainly used to promote ovulation, treat infertility caused by abnormal ovarian function, endometriosis and uterine fibroids, and improve the pregnancy rate.
How to buy Alarelin in the U. S.
Peptide supplier Remetide specializes in the production and sales of Alarelin in the USA, as well as professional peptide custom synthesis service. Feel free to contact us if you have any questions or inquiries about Alarelin Peptide.