KPV, an antimicrobial peptide with unknown mechanism

KPV is a peptide that is naturally produced in the body and is found in the hormone alpha-MSH[1]. It is a potent anti-inflammatory peptide[2] that has shown promise in treating a number of disease conditions, with the most active research being in the area of inflammatory bowel disease[2][3].  It is a relatively newer peptide that is being researched for a number of disease conditions[4]. KPV has been shown in studies to kill Candida albicans[5] and possesses anti-inflammatory properties; however, its mechanisms of action still remain unknown[6].

It is a potent anti-inflammatory peptide that has shown promise in a number of disease conditions[8]. Unlike α-MSH, KPV is free from the melanotropic effects and thus does not cause any pigmentation[9]. Additionally, it is smaller in size and more chemically stable[10]. The most active research is in the treatment of colitis, where KPV has been shown to reduce the incidence of colitis and proinflammatory cytokines[11][12]. KPV has also been shown to have antimicrobial properties[13] and improve overall gut health[13].

Structure

 

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